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TumorDiagnostik & Therapie 2011; 32(1): 48-53
DOI: 10.1055/s-0029-1246043
Thieme Onkologie aktuell

© Georg Thieme Verlag KG Stuttgart · New York

Aktuelle molekular-zytogenetische Aspekte zur Pathologie und Differenzierung von extranodalen Marginalzonen B-Zell-Lymphomen vom MALT-Typ und gastrointestinalen diffusen großzelligen B-Zell-Lymphomen

Current Aspects of the Pathology and Differentiation of Extranodal Marginal Zone B-Cell Lymphoma, MALT-Type, and Gastrointestinal Diffuse Large B-Cell LymphomaL. Floßbach1 , H. A. Kestler2 , 3 , T. M. Gress3 , 4 , P. Möller1 , T. F. E. Barth1
  • 1Institut für Pathologie, Universitätsklinikum Ulm
  • 2Institut für Neuroinformatik, Universität Ulm
  • 3Klinik für Innere Medizin I, Universitätsklinikum Ulm
  • 4Klinik für Gastroenterologie, Endokrinologie und Stoffwechsel, Philipps Universität Marburg
Further Information

Publication History

eingereicht: 23.12.2009

angenommen: 19.4.2010

Publication Date:
01 February 2011 (online)

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Zusammenfassung

Das Marginalzonen B-Zell-Lymphom vom MALT-Typ (MZBL, MT) ist ein häufig im Magen lokalisiertes, niedrig malignes B-Zell-Lymphom mit typischer Morphologie und Zytogenetik. Daneben existieren das gastrointestinale diffuse großzellige B-Zell-Lymphom (DLBCL) und Kompositlymphome (ComL) mit koexistenter groß- und kleinzelliger Zytologie, die aufgrund dessen ein faszinierendes Modell hinsichtlich der Lymphomprogression darstellen. Im vorliegenden Review werden die wichtigsten aktuellen Aspekte zur molekularen Charakterisierung der MZBL, MT und der gastrointestinalen DLBCL sowie einer Relation dieser Lymphomentitäten untereinander zusammengefasst, die sie klar von den nodalen DLBCL abgrenzen.

Abstract

The marginal zone B-cell lymphoma, MALT-type (MZBL, MT) is a low-grade B-cell lymphoma which is predominantly localised in the stomach with a typical morphology and cytogenetic pattern. The coexistence of a diffuse large B-cell lymphoma (DLBCL) with an MZBL, MT in the gastrointestinal tract is defined as a composite lymphoma (ComL) and represents a fascinating model of lymphoma progression. In this review we focus on current aspects regarding the molecular characterisation of MZBL, MT and gastrointestinal DLBCL and their mutual relationships.

Schlüsselwörter

MALT-Lymphom - gastrales DLBCL - Molekularbiologie

Key words

MALT lymphom - gastric DLBCL - molecular biology

Literatur

  • 1 d’Amore F, Christensen B E, Brincker H et al. Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group.  Eur J Cancer. 1991;  27 1201-1208
    Search in Google Scholar
  • 2 Zheng T, Mayne S T, Boyle P et al. Epidemiology of non-Hodgkin lymphoma in Connecticut. 1935 – 1988.  Cancer. 1992;  70 840-849
    Search in Google Scholar
  • 3 A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project.  Blood. 1997;  89 3909-3918
    Search in Google Scholar
  • 4 Newton R, Ferlay J, Beral V et al. The epidemiology of non-Hodgkin’s lymphoma: comparison of nodal and extra-nodal sites.  Int J Cancer. 1997;  72 923-930
    Search in Google Scholar
  • 5 Hussell T, Isaacson P G, Crabtree J E et al. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori.  Lancet. 1993;  342 571-574
    Search in Google Scholar
  • 6 Greiner A, Marx A, Heesemann J et al. Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis.  Lab Invest. 1994;  70 572-578
    Search in Google Scholar
  • 7 Isaacson P G, Du M Q. MALT lymphoma: from morphology to molecules.  Nat Rev Cancer. 2004;  4 644-653
    Search in Google Scholar
  • 8 Isaacson P G, Chott A, Nakamura S et al. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). World Health Organization Classification of Tumours of Hematopoietic and Lymphoid Tisues.  Swerdlow SH Campo E Harris NL et al.. 2008;  214-217
    Search in Google Scholar
  • 9 Wotherspoon A C, Ortiz-Hidalgo C, Falzon M R et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma.  Lancet. 1991;  338 1175-1176
    Search in Google Scholar
  • 10 Karat D, O’Hanlon D M, Hayes N et al. Prospective study of Helicobacter pylori infection in primary gastric lymphoma.  Br J Surg. 1995;  82 1369-1370
    Search in Google Scholar
  • 11 Bouzourene H, Haefliger T, Delacretaz F et al. The role of Helicobacter pylori in primary gastric MALT lymphoma.  Histopathology. 1999;  34 118-123
    Search in Google Scholar
  • 12 Lecuit M, Abachin E, Martin A et al. Immunoproliferative small intestinal disease associated with Campylobacter jejuni.  N Engl J Med. 2004;  350 239-248
    Search in Google Scholar
  • 13 Wundisch T, Mosch C, Neubauer A et al. Helicobacter pylori eradication in gastric mucosa-associated lymphoid tissue lymphoma: Results of a 196-patient series.  Leuk Lymphoma. 2006;  47 2110-2114
    Search in Google Scholar
  • 14 Bayerdorffer E, Neubauer A, Rudolph B et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group.  Lancet. 1995;  345 1591-1594
    Search in Google Scholar
  • 15 Du M Q, Isaccson P G. Gastric MALT lymphoma: from aetiology to treatment.  Lancet Oncol. 2002;  3 97-104
    Search in Google Scholar
  • 16 Fischbach W, Malfertheiner P, Hoffmann J C et al. S3-guideline ”helicobacter pylori and gastroduodenal ulcer disease” of the German society for digestive and metabolic diseases (DGVS) in cooperation with the German society for hygiene and microbiology, society for pediatric gastroenterology and nutrition e. V., German society for rheumatology, AWMF-registration-no. 021 / 001.  Z Gastroenterol. 2009;  47 1230-1263
    Search in Google Scholar
  • 17 Koch P, Probst A, Berdel W E et al. Treatment results in localized primary gastric lymphoma: data of patients registered within the German multicenter study (GIT NHL 02 / 96).  J Clin Oncol. 2005;  23 7050-7059
    Search in Google Scholar
  • 18 Hussell T, Isaacson P G, Crabtree J E et al. Helicobacter pylori-specific tumour-infiltrating T cells provide contact dependent help for the growth of malignant B cells in low-grade gastric lymphoma of mucosa-associated lymphoid tissue.  J Pathol. 1996;  178 122-127
    Search in Google Scholar
  • 19 Nakamura S, Aoyagi K, Furuse M et al. B-cell monoclonality precedes the development of gastric MALT lymphoma in Helicobacter pylori-associated chronic gastritis.  Am J Pathol. 1998;  152 1271-1279
    Search in Google Scholar
  • 20 Ott G, Katzenberger T, Greiner A et al. The t(11;18)(q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue (MALT-) type.  Cancer Res. 1997;  57 3944-3948
    Search in Google Scholar
  • 21 Auer I A, Gascoyne R D, Connors J M et al. t(11;18)(q21;q21) is the most common translocation in MALT lymphomas.  Ann Oncol. 1997;  8 979-985
    Search in Google Scholar
  • 22 Remstein E D, James C D, Kurtin P J. Incidence and subtype specificity of API2-MALT1 fusion translocations in extranodal, nodal, and splenic marginal zone lymphomas.  Am J Pathol. 2000;  156 1183-1188
    Search in Google Scholar
  • 23 Ye H, Liu H, Attygalle A et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.  Blood. 2003;  102 1012-1018
    Search in Google Scholar
  • 24 Remstein E D, Kurtin P J, James C D et al. Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways.  Am J Pathol. 2002;  161 63-71
    Search in Google Scholar
  • 25 Uren A G, O’Rourke K, Aravind L A et al. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.  Mol Cell. 2000;  6 961-967
    Search in Google Scholar
  • 26 Lucas P C, Yonezumi M, Inohara N et al. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway.  J Biol Chem. 2001;  276 19 012-19 019
    Search in Google Scholar
  • 27 Liu H, Ye H, Ruskone-Fourmestraux A et al. T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication.  Gastroenterology. 2002;  122 1286-1294
    Search in Google Scholar
  • 28 Liu H, Ye H, Dogan A et al. T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10.  Blood. 2001;  98 1182-1187
    Search in Google Scholar
  • 29 Streubel B, Simonitsch-Klupp I, Mullauer L et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.  Leukemia. 2004;  18 1722-1726
    Search in Google Scholar
  • 30 Du M, Peng H, Singh N et al. The accumulation of p53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma.  Blood. 1995;  86 4587-4593
    Search in Google Scholar
  • 31 Neumeister P, Hoefler G, Beham-Schmid C et al. Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas.  Gastroenterology. 1997;  112 1871-1875
    Search in Google Scholar
  • 32 Barth T F, Bentz M, Leithauser F et al. Molecular-cytogenetic comparison of mucosa-associated marginal zone B-cell lymphoma and large B-cell lymphoma arising in the gastro-intestinal tract. Genes Chromosomes.  Cancer. 2001;  31 316-325
    Search in Google Scholar
  • 33 Zhou Y, Ye H, Martin-Subero J I et al. Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21).  Br J Haematol. 2006;  133 35-42
    Search in Google Scholar
  • 34 Barth T F, Bentz M, Leithauser F et al. Pathogenic complexity of gastric B-cell lymphoma.  Blood. 2002;  100 1095-1096
    Search in Google Scholar
  • 35 Cabras A D, Candidus S, Fend F et al. Biclonality of gastric lymphomas.  Lab Invest. 2001;  81 961-967
    Search in Google Scholar
  • 36 Barth T F, Dohner H, Werner C A et al. Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract.  Blood. 1998;  91 4321-4330
    Search in Google Scholar
  • 37 Streubel B, Lamprecht A, Dierlamm J et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.  Blood. 2003;  101 2335-2339
    Search in Google Scholar
  • 38 Ye H, Gong L, Liu H et al. MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.  J Pathol. 2005;  205 293-301
    Search in Google Scholar
  • 39 Sanchez-Izquierdo D, Buchonnet G, Siebert R et al. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma.  Blood. 2003;  101 4539-4546
    Search in Google Scholar
  • 40 Dierlamm J, Murga Penas E M, Bentink S et al. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma.  Haematologica. 2008;  93 688-696
    Search in Google Scholar
  • 41 Willis T G, Jadayel D M, Du M Q et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.  Cell. 1999;  96 35-45
    Search in Google Scholar
  • 42 Zhang Q, Siebert R, Yan M et al. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).  Nat Genet. 1999;  22 63-68
    Search in Google Scholar
  • 43 Ye H, Gong L, Liu H et al. Strong BCL10 nuclear expression identifies gastric MALT lymphomas that do not respond to H pylori eradication.  Gut. 2006;  55 137-138
    Search in Google Scholar
  • 44 Thome MCARMA1, BCL-10 and MALT1 in lymphocyte development and activation.  Nat Rev Immunol. 2004;  4 348-359
    Search in Google Scholar
  • 45 Dong G, Liu C, Ye H et al. BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma.  Int J Hematol. 2008;  88 516-523
    Search in Google Scholar
  • 46 Ohshima K, Kawasaki C, Muta H et al. CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD 10 is a marker of improved prognosis.  Histopathology. 2001;  39 156-162
    Search in Google Scholar
  • 47 Streubel B, Vinatzer U, Lamprecht A et al. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.  Leukemia. 2005;  19 652-658
    Search in Google Scholar
  • 48 Wlodarska I, Veyt E, Paepe de P et al. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations.  Leukemia. 2005;  19 1299-1305
    Search in Google Scholar
  • 49 Fenton J A, Schuuring E, Barrans S L et al. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosomes.  Cancer. 2006;  45 164-168
    Search in Google Scholar
  • 50 Ye H, Remstein E D, Bacon C M et al. Chromosomal translocations involving BCL6 in MALT lymphoma.  Haematologica. 2008;  93 145-146
    Search in Google Scholar
  • 51 Chen Y W, Hu X T, Liang A C et al. High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma.  Blood. 2006;  108 2373-2383
    Search in Google Scholar
  • 52 Remstein E D, Dogan A, Einerson R R et al. The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America.  Am J Surg Pathol. 2006;  30 1546-1553
    Search in Google Scholar
  • 53 Nakamura S, Ye H, Bacon C M et al. Clinical impact of genetic aberrations in gastric MALT lymphoma: a comprehensive analysis using interphase fluorescence in situ hybridisation.  Gut. 2007;  56 1358-1363
    Search in Google Scholar
  • 54 Vinatzer U, Gollinger M, Mullauer L et al. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.  Clin Cancer Res. 2008;  14 6426-6431
    Search in Google Scholar
  • 55 Nakamura S, Ye H, Bacon C M et al. Translocations involving the immunoglobulin heavy chain gene locus predict better survival in gastric diffuse large B-cell lymphoma.  Clin Cancer Res. 2008;  14 3002-3010
    Search in Google Scholar
  • 56 Barth T F, Barth C A, Kestler H A et al. Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma.  J Pathol. 2007;  211 305-313
    Search in Google Scholar

Lucia Floßbach

Institut für Pathologie, Universitätsklinikum Ulm

Albert-Einstein-Allee 11

89081 Ulm

Email: lucia.flossbach@uni-ulm.de